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Goal of study is to assess the current level of industry concentration and regional specialization small and medium enterprises in Russia using Krugman indices. The study uses official statistics for 2016, describing the number of enterprises employees located in 80 regions and specializing in 13 types of economic activity. In this research they determine the indices values of enterprises industry concentration and regional specialization. Authors also carry out comparative analysis of changes in the values of these indices for the period from 2010 to 2016. They also establish the patterns characteristic of industry concentration and regional specialization.