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The anaerobic mesophilic degradation of municipal waste has been studied in discontinuous lab-reactors with two different initial concentrations of OFMSW: R20, with 931.1 mg DOC/L (20% TS), and R30, with 1423.4 mg DOC/L (30% TS). The anaerobic digestion process was favoured when it was carried on material with a total solids content of 20% in comparison to a similar process with 30% TS. A higher level of organic matter, in terms of DOC and VFA, 18.18% and 8.09% respect, was removed in the system with the lower amount of solids. The kinetics parameters showed higher active biomass and a higher coefficient for the production of methane at the lower loading. The highest maximum specific growth rate for the microorganisms (μ MAX) in the reactors with 20% TS, a value of 0.192 d− 1, was achieved in comparison to 0.131 d− 1 in the reactors with 30% TS. The inverse of the F: M ratio was higher in the …