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In this article we introduce a notion of depth in the regression setting. It provides the “rank” of any line (plane), rather than ranks of observations or residuals. In simple regression we can compute the depth of any line by a fast algorithm. For any bivariate dataset Z _n of size n there exists a line with depth at least n/3. The largest depth in Z _n can be used as a measure of linearity versus convexity. In both simple and multiple regression we introduce the deepest regression method, which generalizes the univariate median and is equivariant for monotone transformations of the response. Throughout, the errors may be skewed and heteroscedastic. We also consider depth-based regression quantiles. They estimate the quantiles of y given x, as do the Koenker-Bassett regression quantiles, but with the advantage of being robust to leverage outliers. We explore the analogies between depth in regression and in location …