Autores
J Douglas Bremner, Meena Vythilingam, Eric Vermetten, Steven M Southwick, Thomas McGlashan, Ahsan Nazeer, Sarfraz Khan, L Viola Vaccarino, Robert Soufer, Pradeep K Garg, Chin K Ng, Lawrence H Staib, James S Duncan, Dennis S Charney
Fecha de publicación
2003/5/1
Revista
American journal of psychiatry
Volumen
160
Número
5
Páginas
924-932
Editor
American Psychiatric Publishing
Descripción
OBJECTIVE:
Animal studies have suggested that early stress is associated with alterations in the hippocampus, a brain area that plays a critical role in learning and memory. The purpose of this study was to measure both hippocampal structure and function in women with and without early childhood sexual abuse and the diagnosis of posttraumatic stress disorder (PTSD).
METHOD:
Thirty-three women participated in this study, including women with early childhood sexual abuse and PTSD (N= 10), women with abuse without PTSD (N= 12), and women without abuse or PTSD (N= 11). Hippocampal volume was measured with magnetic resonance imaging in all subjects, and hippocampal function during the performance of hippocampal-based verbal declarative memory tasks was measured by using positron emission tomography in abused women with and without PTSD.
RESULTS:
A failure of hippocampal …
Citas totales
Artículos de Google Académico
JD Bremner, M Vythilingam, E Vermetten… - American journal of psychiatry, 2003