Ver artículo

Background Flavonoids have antioxidant and anti-inflammatory properties which could slow down the decline of lung function and reduce risk of chronic obstructive pulmonary disease (COPD), but epidemiological evidence is lacking. Anthocyanins, a subclass of flavonoids, have been detected in lung tissue, and have attenuated mucus and infiltration of inflammatory exudates in experimental models of COPD. Aim To investigate the association between dietary intake of anthocyanins and lung function decline in two representative cohorts of adults in Europe. Methods Participants were 463 adults (44.5±6.3 y at baseline) from England and Norway taking part in the ECRHS2 and ECRHS3 surveys, with valid spirometry and dietary data collected at both baseline (2002) and follow-up (2012). To investigate the effect of anthocyanin intake on forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and …