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ContextPlasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke.ObjectiveTo assess the relationships of fibrinogen levels with risk of major vascular and with risk of nonvascular outcomes based on individual participant data.Data SourcesRelevant studies were identified by computer-assisted searches, hand searches of reference lists, and personal communication with relevant investigators.Study SelectionAll identified prospective studies were included with information available on baseline fibrinogen levels and details of subsequent major vascular morbidity and/or cause-specific mortality during at least 1 year of follow-up. Studies were excluded if they recruited participants on the basis of having had a previous history of cardiovascular disease; participants with known preexisting CHD or stroke were excluded.Data ExtractionIndividual records were provided on each of …