Autores
Jürgen Krücken, Kira Fraundorfer, Jean Claude Mugisha, Sabrina Ramünke, Kevin C Sifft, Dominik Geus, Felix Habarugira, Jules Ndoli, Augustin Sendegeya, Caritas Mukampunga, Claude Bayingana, Toni Aebischer, Janina Demeler, Jean Bosco Gahutu, Frank P Mockenhaupt, Georg von Samson-Himmelstjerna
Fecha de publicación
2017/12/1
Revista
International Journal for Parasitology: Drugs and Drug Resistance
Volumen
7
Número
3
Páginas
262-271
Editor
Elsevier
Descripción
Control of human soil-transmitted helminths (STHs) relies on preventive chemotherapy of schoolchildren applying the benzimidazoles (BZ) albendazole or mebendazole. Anthelmintic resistance (AR) is a common problem in nematodes of veterinary importance but for human STHs, information on drug efficacy is limited and routine monitoring is rarely implemented. Herein, the efficacy of single dose albendazole (400 mg) was evaluated in 12 schools in the Huye district of Rwanda where Ascaris is the predominant STH. Ascaris eggs were detected by wet mount microscopy and the Mini-FLOTAC method to assess cure rate (CR) and faecal egg count reduction (FECR). Blood and faecal samples were analysed for co-infections with Plasmodium sp. and Giardia duodenalis, respectively. Ascaris positive samples collected before and after treatment were analysed for putatively BZ-resistance associated β-tubulin gene …
Artículos de Google Académico
J Krücken, K Fraundorfer, JC Mugisha, S Ramünke… - International Journal for Parasitology: Drugs and Drug …, 2017