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The main purpose of this study was to prepare a novel in situ gel system for nasal delivery of MF and study its efficacy on allergic rhinitis model. An ion-activated in situ gel was developed and characterized with gellan gum as a carrier. The system was stable kept at 40 ± 2 °C for 6 months, and the micrographic results showed that in situ gel was safety without mucosa irritation when given at 20 μg once daily for 1 month to rats with allergic rhinitis. MF in gellan gum produced obviously effect on allergic rhinitis at the doses of 20 μg/body following intranasal administration, and the efficacy was significantly superior to that of the common suspension (P < 0.01). The in situ gel system is a promising approach for the intranasal delivery of MF for the therapeutic effects improvement.