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The experiment was carried out to determine coefficient of phenotypic, genotypic and environmental correlations and path coefficients (at genotypic level) between seed cotton yield and its components in six upland cotton cultivars and their 15 hybrids, and to determine the coefficient of variation, heritability and genetic advance of these traits at Jusepín, Monagas State, Venezuela. Traits with larger coefficients of genotypic variation were set flowers (24.5%), sympodial branches (20.3%) and at phenotypic level were set flowers (33.3%) and bolls/plant (32.3%). Broad-sense heritability estimates were highest for blooming initiation (96.9%), fiber fineness (80.0%) and stem diameter (64.6%). Expected genetic advances as percentage of the mean were highest for set flowers (37.0%) and sympodial branches (32.1%). Seed cotton yield ha-1 was significantly positively correlated with bolls/plant at both phenotypic and environmental level, while at genotypic level the correlation was significant and positive with fiber length, bolls/plant, flowers/plant, boll weight, sympodial branches/plant, 100-seed weight, and negative with fiber strength. Path analysis indicated that components with maximum direct effects on seed cotton yield were sympodial branches (5.380) and effective boll set (4.993), but these characters being annulated each other. The character that showed a positive correlation (0.532) and a direct positive effect (2.397), being not altered by rest of the components was boll weight, indicating its potential use as a selection criterion to increase the seed cotton yield.