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This paper summarizes the main findings of the GLAMUR project which starts with an apparently simple question: is “local” more sustainable than “global”? Sustainability assessment is framed within a post-normal science perspective, advocating the integration of public deliberation and scientific research. The assessment spans 39 local, intermediate and global supply chain case studies across different commodities and countries. Assessment criteria cover environmental, economic, social, health and ethical sustainability dimensions. A closer view of the food system demonstrates a highly dynamic local–global continuum where actors, while adapting to a changing environment, establish multiple relations and animate several chain configurations. The evidence suggests caution when comparing “local” and “global” chains, especially when using the outcomes of the comparison in decision-making. Supply chains are analytical constructs that necessarily—and arbitrarily—are confined by system boundaries, isolating a set of elements from an interconnected whole. Even consolidated approaches, such as Life Cycle Assessment (LCA), assess only a part of sustainability attributes, and the interpretation may be controversial. Many sustainability attributes are not yet measurable and “hard” methodologies need to be complemented by “soft” methodologies which are at least able to identify critical issues and trade-offs. Aware of these limitations, our research shows that comparing local and global chains, with the necessary caution, can help overcome a priori positions that so far have characterized the debate between “localists” and “globalists”. At …