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The operation of a wastewater treatment plant treating effluents from a dairy laboratory was monitored by an advanced system. This plant comprises a 12 m³ anaerobic filter (AF) reactor and a 28 m³ sequential batch reactor (SBR) coupled in series and is equipped with the following on‐line measurement devices: biogas flow meter, feed and recycling flow meters, temperature sensor, dissolved oxygen analyzer, and redox meter. Other parameters such as chemical oxygen demand (COD), volatile fatty acids (VFA), etc. were determined off‐line. The plant has been in operation for 634 days, the influent flow rate being 6–8 m³/d. COD concentration of the influent ranged between 8 and 12 kg COD/m³, resulting in COD values in the effluent around 50–200 mg/L. The behavior of the system was studied using the set of measurements collected by the data acquisition program especially developed for this purpose …