Autores
M Perez Busquier, E Calero, M Rodriguez, P Castellon Arce, A Bermudez, LF Linares, J Mesa, C Ffernandez Crisostomos, C Garcia, A Garcia Lopez, A Valenzuela, A Povedano, S Garcia Perez, MA Lopez, R Caliz, F Garcia Villalba, M Cano, F Gines Martinez, J Gonzalez, MA Caracuel, R Roldan, M Guzman Ubeda, A Gonzalez, IL Marenco de la Fuente, E Rejon, F Navarro Sarabia, J Prieto, JM Rodriguez, M Riesco Diaz, F Manzano, J Perezbenegas, M Alepuz Pou
Fecha de publicación
1997/3
Revista
Clinical rheumatology
Volumen
16
Número
2
Páginas
154-159
Editor
Springer-Verlag
Descripción
A multicentre, double-blind, randomised, parallel group study was undertaken to investigate the efficacy and safety of aceclofenac (123 patients, 100 mg twice daily) in comparison to piroxicam (117 patients, 20 mg once daily and placebo once daily) in patients with osteoarthritis of the knee. The treatment period of two months was preceded by a washout period of one week duration. On completion of the study, patients in both aceclofenac and piroxicam-treated groups exhibited significant improvement in pain intensity and functional capacity of the affected knee, as represented by the Osteoarthritis Severity Index (OSI) (p<0.0001 and p<0.001 respectively). This was further substantiated following the patient's assessment of pain intensity using the Visual Analogue Scale (VAS), in which significant improvements were demonstrated at all time points for each treatment group (p<0.001). Although both treatment …
Citas totales
Artículos de Google Académico
MP Busquier, E Calero, M Rodriguez, PC Arce… - Clinical rheumatology, 1997