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Personality is suggested to be a major risk factor for depression but large‐scale individual participant meta‐analyses on this topic are lacking.

Data from 10 prospective community cohort studies with 117,899 participants (mean age 49.0 years; 54.7% women) were pooled for individual participant meta‐analysis to determine the association between personality traits of the five‐factor model and risk of depressive symptoms.

In cross‐sectional analysis, low extraversion (pooled standardized regression coefficient (B) = –.08; 95% confidence interval = –0.11, –0.04), high neuroticism (B = .39; 0.32, 0.45), and low conscientiousness (B = –.09; –0.10, –0.06) were associated with depressive symptoms. Similar associations were observed in longitudinal analyses adjusted for baseline depressive symptoms (n = 56,735; mean follow‐up of 5.0 years): low extraversion (B = –.03; –0.05, –0.01 …