Autores
MC Kapulu, DF Da, K Miura, Y Li, AM Blagborough, TS Churcher, D Nikolaeva, Andrew Richard Williams, AL Goodman, I Sangare, AV Turner, MG Cottingham, A Nicosia, U Straschil, T Tsuboi, SC Gilbert, Carole A Long, RE Sinden, SJ Draper, AVS Hill, Anna Cohuet, S Biswas
Fecha de publicación
2015/6/11
Revista
Scientific reports
Volumen
5
Páginas
11193
Editor
Nature Publishing Group
Descripción
Malaria transmission-blocking vaccines (TBVs) target the development of Plasmodium parasites within the mosquito, with the aim of preventing malaria transmission from one infected individual to another. Different vaccine platforms, mainly protein-in-adjuvant formulations delivering the leading candidate antigens, have been developed independently and have reported varied transmission-blocking activities (TBA). Here, recombinant chimpanzee adenovirus 63, ChAd63 and modified vaccinia virus Ankara, MVA, expressing AgAPN1, Pfs230-C, Pfs25 and Pfs48/45 were generated. Antibody responses primed individually against all antigens by ChAd63 immunization in BALB/c mice were boosted by the administration of MVA expressing the same antigen. These antibodies exhibited a hierarchy of inhibitory activity against the NF54 laboratory strain of P. falciparum in Anopheles stephensi mosquitoes using the …
Artículos de Google Académico
MC Kapulu, DF Da, K Miura, Y Li, AM Blagborough… - Scientific reports, 2015