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The notion of distinct national varieties or systems of capitalism gained considerable currency in the last two decades. This review essay highlights three theoretical premises which define what we call the comparative capitalisms (CC) approach to political economy: First, national economies are characterized by distinct institutional configurations; second, these configurations are a source of comparative institutional advantage; and third, the configurations are stabilized by institutional path dependence. Within these common premises, the CC literature contains a number of competing theories and we highlight the fundamental distinctions among them and draw out their respective limitations. We specifically examine the role of politics within the CC literature and how emerging conceptions of politics may contribute to understanding institutional change in capitalist systems.