| Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library H Koike-Yusa, Y Li, EP Tan, MDC Velasco-Herrera, K Yusa Nature biotechnology 32 (3), 267, 2014 | 691 | 2014 |
| Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells K Yusa, ST Rashid, H Strick-Marchand, I Varela, PQ Liu, DE Paschon, ... Nature 478 (7369), 391, 2011 | 617 | 2011 |
| Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon K Yusa, R Rad, J Takeda, A Bradley Nature methods 6 (5), 363, 2009 | 615 | 2009 |
| Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency‐associated genes P Mali, BK Chou, J Yen, Z Ye, J Zou, S Dowey, RA Brodsky, JE Ohm, ... Stem cells 28 (4), 713-720, 2010 | 421 | 2010 |
| A hyperactive piggyBac transposase for mammalian applications K Yusa, L Zhou, MA Li, A Bradley, NL Craig Proceedings of the National Academy of Sciences 108 (4), 1531-1536, 2011 | 341 | 2011 |
| PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice R Rad, L Rad, W Wang, J Cadinanos, G Vassiliou, S Rice, LS Campos, ... Science 330 (6007), 1104-1107, 2010 | 200 | 2010 |
| A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ... Cell reports 17 (4), 1193-1205, 2016 | 185 | 2016 |
| Characterization of Sleeping Beauty transposition and its application to genetic screening in mice K Horie, K Yusa, K Yae, J Odajima, SEJ Fischer, VW Keng, T Hayakawa, ... Molecular and cellular biology 23 (24), 9189-9207, 2003 | 162 | 2003 |
| Mobilization of giant piggyBac transposons in the mouse genome MA Li, DJ Turner, Z Ning, K Yusa, Q Liang, S Eckert, L Rad, TW Fitzgerald, ... Nucleic acids research 39 (22), e148-e148, 2011 | 132 | 2011 |
| A genetic progression model of BrafV600E-induced intestinal tumorigenesis reveals targets for therapeutic intervention R Rad, J Cadiñanos, L Rad, I Varela, A Strong, L Kriegl, ... Cancer cell 24 (1), 15-29, 2013 | 128 | 2013 |
| Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system VW Keng, K Yae, T Hayakawa, S Mizuno, Y Uno, K Yusa, C Kokubu, ... Nature methods 2 (10), 763, 2005 | 127 | 2005 |
| Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation K Yusa, J Takeda, K Horie Molecular and cellular biology 24 (9), 4004-4018, 2004 | 97 | 2004 |
| Hyperactive piggyBac gene transfer in human cells and in vivo JE Doherty, LE Huye, K Yusa, L Zhou, NL Craig, MH Wilson Human gene therapy 23 (3), 311-320, 2011 | 74 | 2011 |
| Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene K Yusa, K Horie, G Kondoh, M Kouno, Y Maeda, T Kinoshita, J Takeda Nature 429 (6994), 896, 2004 | 74 | 2004 |
| Seamless genome editing in human pluripotent stem cells using custom endonuclease–based gene targeting and the piggyBac transposon K Yusa Nature protocols 8 (10), 2061, 2013 | 64 | 2013 |
| Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens FM Behan, F Iorio, G Picco, E Gonçalves, CM Beaver, G Migliardi, ... Nature 568 (7753), 511, 2019 | 62 | 2019 |
| Sleeping beauty transposase has an affinity for heterochromatin conformation R Ikeda, C Kokubu, K Yusa, VW Keng, K Horie, J Takeda Molecular and cellular biology 27 (5), 1665-1676, 2007 | 60 | 2007 |
| Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development K Miyamoto, M Teperek, K Yusa, GE Allen, CR Bradshaw, JB Gurdon Science 341 (6149), 1002-1005, 2013 | 56 | 2013 |
| The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation A Nijnik, S Clare, C Hale, C Raisen, RE McIntyre, K Yusa, AR Everitt, ... Blood, The Journal of the American Society of Hematology 119 (6), 1370-1379, 2012 | 55 | 2012 |
| The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites MA Li, SJ Pettitt, S Eckert, Z Ning, S Rice, J Cadiñanos, K Yusa, N Conte, ... Molecular and cellular biology 33 (7), 1317-1330, 2013 | 52 | 2013 |
Allan BradleySenior Group Leader and Director Emeritus, Wellcome Trust Sanger InstituteDirección de correo verificada de sanger.ac.uk
