| Initial sequencing and analysis of the human genome International Human Genome Sequencing Consortium NATURE-LONDON- 441 (7093), 30, 2006 | 23972* | 2006 |
| Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 M Tahiliani, KP Koh, Y Shen, WA Pastor, H Bandukwala, Y Brudno, ... Science 324 (5929), 930-935, 2009 | 4345 | 2009 |
| AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes AF Neuwald, L Aravind, JL Spouge, EV Koonin Genome research 9 (1), 27-43, 1999 | 1950 | 1999 |
| Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis RS Stephens, S Kalman, C Lammel, J Fan, R Marathe, L Aravind, ... Science 282 (5389), 754-759, 1998 | 1685 | 1998 |
| De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling IE Wertz, KM O'rourke, H Zhou, M Eby, L Aravind, S Seshagiri, P Wu, ... Nature 430 (7000), 694, 2004 | 1669 | 2004 |
| Bacterial rhodopsin: evidence for a new type of phototrophy in the sea O Béja, L Aravind, EV Koonin, MT Suzuki, A Hadd, LP Nguyen, ... Science 289 (5486), 1902-1906, 2000 | 1430 | 2000 |
| Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements AA Schäffer, L Aravind, TL Madden, S Shavirin, JL Spouge, YI Wolf, ... Nucleic acids research 29 (14), 2994-3005, 2001 | 1360 | 2001 |
| Horizontal gene transfer in prokaryotes: quantification and classification EV Koonin, KS Makarova, L Aravind Annual Reviews in Microbiology 55 (1), 709-742, 2001 | 1142 | 2001 |
| Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma AG Uren, K O'Rourke, L Aravind, MT Pisabarro, S Seshagiri, EV Koonin, ... Molecular cell 6 (4), 961-967, 2000 | 1113 | 2000 |
| Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 M Ko, Y Huang, AM Jankowska, UJ Pape, M Tahiliani, HS Bandukwala, ... Nature 468 (7325), 839, 2010 | 1102 | 2010 |
| Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome R Verma, L Aravind, R Oania, WH McDonald, JR Yates, EV Koonin, ... Science 298 (5593), 611-615, 2002 | 1050 | 2002 |
| Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1 O White, JA Eisen, JF Heidelberg, EK Hickey, JD Peterson, RJ Dodson, ... Science 286 (5444), 1571-1577, 1999 | 1038 | 1999 |
| Classification and evolution of P-loop GTPases and related ATPases DD Leipe, YI Wolf, EV Koonin, L Aravind Journal of molecular biology 317 (1), 41-72, 2002 | 1015 | 2002 |
| Complete genome sequence of the apicomplexan, Cryptosporidium parvum MS Abrahamsen, TJ Templeton, S Enomoto, JE Abrahante, G Zhu, ... Science 304 (5669), 441-445, 2004 | 959 | 2004 |
| Structure and evolution of transcriptional regulatory networks MM Babu, NM Luscombe, L Aravind, M Gerstein, SA Teichmann Current opinion in structural biology 14 (3), 283-291, 2004 | 831 | 2004 |
| Evolutionary history and higher order classification of AAA+ ATPases LM Iyer, DD Leipe, EV Koonin, L Aravind Journal of structural biology 146 (1-2), 11-31, 2004 | 755 | 2004 |
| Genome of the extremely radiation-resistant bacterium Deinococcus radiodurans viewed from the perspective of comparative genomics KS Makarova, L Aravind, YI Wolf, RL Tatusov, KW Minton, EV Koonin, ... Microbiol. Mol. Biol. Rev. 65 (1), 44-79, 2001 | 724 | 2001 |
| Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 GA Cope, GSB Suh, L Aravind, SE Schwarz, SL Zipursky, EV Koonin, ... Science 298 (5593), 608-611, 2002 | 693 | 2002 |
| The GAF domain: an evolutionary link between diverse phototransducing proteins L Aravind, CP Ponting Trends in biochemical sciences 12 (22), 458-459, 1997 | 616 | 1997 |
| Conserved domains in DNA repair proteins and evolution of repair systems L Aravind, DR Walker, EV Koonin Nucleic acids research 27 (5), 1223-1242, 1999 | 604 | 1999 |