| SMARTCyp: a 2D method for prediction of cytochrome P450-mediated drug metabolism P Rydberg, DE Gloriam, J Zaretzki, C Breneman, L Olsen ACS medicinal chemistry letters 1 (3), 96-100, 2010 | 189 | 2010 |
| On the role of the axial ligand in heme proteins: a theoretical study P Rydberg, E Sigfridsson, U Ryde JBIC Journal of Biological Inorganic Chemistry 9 (2), 203-223, 2004 | 186 | 2004 |
| Structures of the high-valent metal-ion haem–oxygen intermediates in peroxidases, oxygenases and catalases HP Hersleth, U Ryde, P Rydberg, CH Görbitz, KK Andersson Journal of inorganic biochemistry 100 (4), 460-476, 2006 | 159 | 2006 |
| Prediction of activation energies for hydrogen abstraction by cytochrome P450 L Olsen, P Rydberg, TH Rod, U Ryde Journal of medicinal chemistry 49 (22), 6489-6499, 2006 | 108 | 2006 |
| The SMARTCyp cytochrome P450 metabolism prediction server P Rydberg, DE Gloriam, L Olsen Bioinformatics 26 (23), 2988-2989, 2010 | 97 | 2010 |
| RS-predictor: a new tool for predicting sites of cytochrome P450-mediated metabolism applied to CYP 3A4 J Zaretzki, C Bergeron, P Rydberg, T Huang, KP Bennett, CM Breneman Journal of chemical information and modeling 51 (7), 1667-1689, 2011 | 80 | 2011 |
| RS-Predictor models augmented with SMARTCyp reactivities: robust metabolic regioselectivity predictions for nine CYP isozymes J Zaretzki, P Rydberg, C Bergeron, KP Bennett, L Olsen, CM Breneman Journal of chemical information and modeling 52 (6), 1637-1659, 2012 | 67 | 2012 |
| Sulfoxide, sulfur, and nitrogen oxidation and dealkylation by cytochrome P450 P Rydberg, U Ryde, L Olsen Journal of chemical theory and computation 4 (8), 1369-1377, 2008 | 64 | 2008 |
| Fast prediction of cytochrome P450 mediated drug metabolism P Rydberg, P Vasanthanathan, C Oostenbrink, L Olsen ChemMedChem 4 (12), 2070-2079, 2009 | 54 | 2009 |
| Prediction of activation energies for aromatic oxidation by cytochrome P450 P Rydberg, U Ryde, L Olsen The journal of physical chemistry A 112 (50), 13058-13065, 2008 | 49 | 2008 |
| Dynamics of water molecules in the active-site cavity of human cytochromes P450 P Rydberg, TH Rod, L Olsen, U Ryde The Journal of Physical Chemistry B 111 (19), 5445-5457, 2007 | 49 | 2007 |
| General transition-state force field for cytochrome P450 hydroxylation P Rydberg, L Olsen, PO Norrby, U Ryde Journal of chemical theory and computation 3 (5), 1765-1773, 2007 | 48 | 2007 |
| Binding affinities in the SAMPL3 trypsin and host–guest blind tests estimated with the MM/PBSA and LIE methods P Mikulskis, S Genheden, P Rydberg, L Sandberg, L Olsen, U Ryde Journal of computer-aided molecular design 26 (5), 527-541, 2012 | 46 | 2012 |
| FAst MEtabolizer (FAME): A rapid and accurate predictor of sites of metabolism in multiple species by endogenous enzymes J Kirchmair, MJ Williamson, AM Afzal, JD Tyzack, APK Choy, A Howlett, ... Journal of chemical information and modeling 53 (11), 2896-2907, 2013 | 45 | 2013 |
| Predicting drug metabolism by cytochrome P450 2C9: comparison with the 2D6 and 3A4 isoforms P Rydberg, L Olsen ChemMedChem 7 (7), 1202-1209, 2012 | 44 | 2012 |
| Ligand-based Site of Metabolism Prediction for Cytochrome P450 2D6 P Rydberg, L Olsen ACS Medicinal Chemistry Letters 3 (1), 69-73, 2012 | 42 | 2012 |
| The accuracy of geometries for iron porphyrin complexes from density functional theory P Rydberg, L Olsen The Journal of Physical Chemistry A 113 (43), 11949-11953, 2009 | 42 | 2009 |
| WhichCyp: prediction of cytochromes P450 inhibition M Rostkowski, O Spjuth, P Rydberg Bioinformatics 29 (16), 2051-2052, 2013 | 38 | 2013 |
| The contribution of atom accessibility to site of metabolism models for cytochromes P450 P Rydberg, M Rostkowski, DE Gloriam, L Olsen Molecular pharmaceutics 10 (4), 1216-1223, 2013 | 31 | 2013 |
| Protonation of the proximal histidine ligand in heme peroxidases J Heimdal, P Rydberg, U Ryde The Journal of Physical Chemistry B 112 (8), 2501-2510, 2008 | 28 | 2008 |
Lars OlsenDepartment of Drug Design and Pharmacology, University of CopenhagenVerified email at novozymes.com
