| TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities R Samarakoon, JM Overstreet, PJ Higgins Cellular signalling 25 (1), 264-268, 2013 | 254 | 2013 |
| PAI-1: an integrator of cell signaling and migration RP Czekay, CE Wilkins-Port, SP Higgins, J Freytag, JM Overstreet, ... International journal of cell biology 2011, 2011 | 146 | 2011 |
| TGF-β1→ SMAD/p53/USF2→ PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis R Samarakoon, JM Overstreet, SP Higgins, PJ Higgins Cell and tissue research 347 (1), 117-128, 2012 | 119 | 2012 |
| Integration of non-SMAD and SMAD signaling in TGF-β1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells R Samarakoon, PJ Higgins Thrombosis and haemostasis 100 (12), 976-983, 2008 | 119 | 2008 |
| Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species R Samarakoon, AD Dobberfuhl, C Cooley, JM Overstreet, S Patel, ... Cellular signalling 25 (11), 2198-2209, 2013 | 110 | 2013 |
| TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling R Samarakoon, SP Higgins, CE Higgins, PJ Higgins Journal of molecular and cellular cardiology 44 (3), 527-538, 2008 | 96 | 2008 |
| TGF-β1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling SM Kutz, CE Higgins, R Samarakoon, SP Higgins, RR Allen, L Qi, ... Experimental cell research 312 (7), 1093-1105, 2006 | 79 | 2006 |
| Plasminogen activator inhibitor type‐1 gene expression and induced migration in TGF‐β1‐stimulated smooth muscle cells is pp60c‐src/MEK‐dependent R Samarakoon, CE Higgins, SP Higgins, SM Kutz, PJ Higgins Journal of cellular physiology 204 (1), 236-246, 2005 | 61 | 2005 |
| Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity JM Overstreet, R Samarakoon, KK Meldrum, PJ Higgins Cellular signalling 26 (7), 1427-1436, 2014 | 53 | 2014 |
| Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression R Samarakoon, SS Chitnis, SP Higgins, CE Higgins, JC Krepinsky, ... PloS one 6 (7), e22896, 2011 | 52 | 2011 |
| Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF R Samarakoon, M Goppelt-Struebe, PJ Higgins Cellular signalling 22 (10), 1413-1419, 2010 | 49 | 2010 |
| MEK/ERK pathway mediates cell-shape-dependent plasminogen activator inhibitor type 1 gene expression upon drug-induced disruption of the microfilament and microtubule networks R Samarakoon, PJ Higgins J Cell Sci 115 (15), 3093-3103, 2002 | 48 | 2002 |
| SERPINE1 (PAI-1) is deposited into keratinocyte migration “trails” and required for optimal monolayer wound repair KM Providence, SP Higgins, A Mullen, A Battista, R Samarakoon, ... Archives of dermatological research 300 (6), 303-310, 2008 | 46 | 2008 |
| PAI-1 mediates the TGF-β1+ EGF-induced “scatter” response in transformed human keratinocytes J Freytag, CE Wilkins-Port, CE Higgins, SP Higgins, R Samarakoon, ... Journal of Investigative Dermatology 130 (9), 2179-2190, 2010 | 44 | 2010 |
| Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption R Samarakoon, CE Higgins, SP Higgins, PJ Higgins Cellular signalling 21 (6), 986-995, 2009 | 44 | 2009 |
| The role of the p53 tumor suppressor in metabolism and diabetes CP Kung, ME Murphy The Journal of endocrinology 231 (2), R61, 2016 | 42 | 2016 |
| Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3‐and p53‐dependent fibrotic responses R Samarakoon, S Helo, AD Dobberfuhl, NS Khakoo, L Falke, ... The Journal of pathology 236 (4), 421-432, 2015 | 37 | 2015 |
| TGF-1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy R Samarakoon, CE Higgins, SP Higgins, PJ Higgins Journal of oncology 2009, 2009 | 33 | 2009 |
| pp60c‐src mediates ERK activation/nuclear localization and PAI‐1 gene expression in response to cellular deformation R Samarakoon, PJ Higgins Journal of cellular physiology 195 (3), 411-420, 2003 | 24 | 2003 |
| PAI-1 regulates the invasive phenotype in human cutaneous squamous cell carcinoma J Freytag, CE Wilkins-Port, CE Higgins, JA Carlson, A Noel, JM Foidart, ... Journal of oncology 2009, 2009 | 23 | 2009 |
Jessica OverstreetEli LillyDirección de correo verificada de lilly.com
