| TGFβ signaling in growth control, cancer, and heritable disorders J Massagué, SW Blain, RS Lo Cell 103 (2), 295-309, 2000 | 2739 | 2000 |
| Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation R Nazarian, H Shi, Q Wang, X Kong, RC Koya, H Lee, Z Chen, MK Lee, ... Nature 468 (7326), 973, 2010 | 1907 | 2010 |
| Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion R Straussman, T Morikawa, K Shee, M Barzily-Rokni, ZR Qian, J Du, ... Nature 487 (7408), 500, 2012 | 1369 | 2012 |
| RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E) PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ... Nature 480 (7377), 387, 2011 | 1171 | 2011 |
| Mutations associated with acquired resistance to PD-1 blockade in melanoma JM Zaretsky, A Garcia-Diaz, DS Shin, H Escuin-Ordinas, W Hugo, ... New England Journal of Medicine 375 (9), 819-829, 2016 | 1068 | 2016 |
| RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors F Su, A Viros, C Milagre, K Trunzer, G Bollag, O Spleiss, JS Reis-Filho, ... New England Journal of Medicine 366 (3), 207-215, 2012 | 906 | 2012 |
| Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma W Hugo, JM Zaretsky, L Sun, C Song, BH Moreno, S Hu-Lieskovan, ... Cell 165 (1), 35-44, 2016 | 902 | 2016 |
| Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma M Krauthammer, Y Kong, BH Ha, P Evans, A Bacchiocchi, JP McCusker, ... Nature genetics 44 (9), 1006, 2012 | 893 | 2012 |
| Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy H Shi, W Hugo, X Kong, A Hong, RC Koya, G Moriceau, T Chodon, R Guo, ... Cancer discovery 4 (1), 80-93, 2014 | 614 | 2014 |
| A Smad transcriptional corepressor D Wotton, RS Lo, S Lee, J Massagué Cell 97 (1), 29-39, 1999 | 589 | 1999 |
| Melanoma whole-exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance H Shi, G Moriceau, X Kong, MK Lee, H Lee, RC Koya, C Ng, T Chodon, ... Nature communications 3, 724, 2012 | 560 | 2012 |
| A structural basis for mutational inactivation of the tumour suppressor Smad4 Y Shi, A Hata, RS Lo, J Massague, NP Pavletich Nature 388 (6637), 87, 1997 | 516 | 1997 |
| Determinants of specificity in TGF-β signal transduction YG Chen, A Hata, RS Lo, D Wotton, Y Shi, N Pavletich, J Massagué Genes & development 12 (14), 2144-2152, 1998 | 418 | 1998 |
| Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 A Hata, RS Lo, D Wotton, G Lagna, J Massague Nature 388 (6637), 82, 1997 | 418 | 1997 |
| Ubiquitin-dependent degradation of TGF-β-activated Smad2 RS Lo, J Massagué Nature cell biology 1 (8), 472, 1999 | 407 | 1999 |
| Primary resistance to PD-1 blockade mediated by JAK1/2 mutations DS Shin, JM Zaretsky, H Escuin-Ordinas, A Garcia-Diaz, S Hu-Lieskovan, ... Cancer discovery 7 (2), 188-201, 2017 | 357 | 2017 |
| Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma K Trunzer, AC Pavlick, L Schuchter, R Gonzalez, GA McArthur, TE Hutson, ... Journal of clinical oncology 31 (14), 1767-1774, 2013 | 328 | 2013 |
| Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression A Garcia-Diaz, DS Shin, BH Moreno, J Saco, H Escuin-Ordinas, ... Cell reports 19 (6), 1189-1201, 2017 | 294 | 2017 |
| Etiology and outcome of diarrhea after marrow transplantation: a prospective study GJ Cox, SM Matsui, RS Lo, M Hinds, RA Bowden, RC Hackman, ... Gastroenterology 107 (5), 1398-1407, 1994 | 286 | 1994 |
| The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptors RS Lo, YG Chen, Y Shi, NP Pavletich, J Massagué The EMBO journal 17 (4), 996-1005, 1998 | 281 | 1998 |
