| Rapid pneumococcal evolution in response to clinical interventions NJ Croucher, SR Harris, C Fraser, MA Quail, J Burton, M van der Linden, ... science 331 (6016), 430-434, 2011 | 769 | 2011 |
| A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae B Martin, O Humbert, M Camara, E Guenzi, J Walker, T Mitchell, P Andrew, ... Nucleic acids research 20 (13), 3479-3483, 1992 | 458 | 1992 |
| Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis JS Braun, JE Sublett, D Freyer, TJ Mitchell, JL Cleveland, EI Tuomanen, ... The Journal of clinical investigation 109 (1), 19-27, 2002 | 336 | 2002 |
| MOLECULAR ANALYSIS OF THE PATHOGENICITY OF STREPTOCOCCUS PNEUMONIAE: The Role of Pneumococcal Proteins JC Paton, PW Andrew, GJ Boulnois, TJ Mitchell Annual review of microbiology 47 (1), 89-115, 1993 | 320 | 1993 |
| The pathogenesis of streptococcal infections: from tooth decay to meningitis TJ Mitchell Nature Reviews Microbiology 1 (3), 219, 2003 | 312 | 2003 |
| Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements S Guiral, TJ Mitchell, B Martin, JP Claverys Proceedings of the National Academy of Sciences 102 (24), 8710-8715, 2005 | 299 | 2005 |
| Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species C Donati, NL Hiller, H Tettelin, A Muzzi, NJ Croucher, SV Angiuoli, ... Genome biology 11 (10), R107, 2010 | 296 | 2010 |
| Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. JE Alexander, RA Lock, CC Peeters, JT Poolman, PW Andrew, TJ Mitchell, ... Infection and immunity 62 (12), 5683-5688, 1994 | 253 | 1994 |
| Microarray-based identification of a novelStreptococcus pneumoniae regulon controlled by an autoinduced peptide A De Saizieu, C Gardès, N Flint, C Wagner, M Kamber, TJ Mitchell, ... Journal of Bacteriology 182 (17), 4696-4703, 2000 | 248 | 2000 |
| Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes. S Houldsworth, PW Andrew, TJ Mitchell Infection and immunity 62 (4), 1501-1503, 1994 | 240 | 1994 |
| Streptococcus pneumoniae: virulence factors and variation AM Mitchell, TJ Mitchell Clinical Microbiology and Infection 16 (5), 411-418, 2010 | 239 | 2010 |
| Host cellular immune response to pneumococcal lung infection in mice A Kadioglu, NA Gingles, K Grattan, A Kerr, TJ Mitchell, PW Andrew Infection and immunity 68 (2), 492-501, 2000 | 221 | 2000 |
| The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia M Witzenrath, F Pache, D Lorenz, U Koppe, B Gutbier, C Tabeling, ... The Journal of Immunology 187 (1), 434-440, 2011 | 217 | 2011 |
| The role of pneumolysin and autolysin in the pathology of pneumonia and septicemia in mice infected with a type 2 pneumococcus JR Canvin, AP Marvin, M Sivakumaran, JC Paton, GJ Boulnois, ... Journal of Infectious Diseases 172 (1), 119-123, 1995 | 215 | 1995 |
| Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute‐phase protein TJ Mitchell, PW Andrew, FK Saunders, AN Smith, GJ Boulnois Molecular microbiology 5 (8), 1883-1888, 1991 | 198 | 1991 |
| Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. JC Paton, RA Lock, CJ Lee, JP Li, AM Berry, TJ Mitchell, PW Andrew, ... Infection and immunity 59 (7), 2297-2304, 1991 | 182 | 1991 |
| A neuraminidase from Streptococcus pneumoniae has the features of a surface protein. M Camara, GJ Boulnois, PW Andrew, TJ Mitchell Infection and immunity 62 (9), 3688-3695, 1994 | 181 | 1994 |
| Pneumolysin: a double-edged sword during the host-pathogen interaction HM Marriott, TJ Mitchell, DH Dockrell Current molecular medicine 8 (6), 497-509, 2008 | 179 | 2008 |
| The biology of Gram-positive sortase enzymes GK Paterson, TJ Mitchell Trends in microbiology 12 (2), 89-95, 2004 | 174 | 2004 |
| Structure and function of pneumolysin, the multifunctional, thiol‐activated toxin of Streptococcus pneumoniae GJ Boulnois, JC Paton, TJ Mitchell, PW Andrew Molecular microbiology 5 (11), 2611-2616, 1991 | 167 | 1991 |
Charles FeldmanProfessor of Pulmonlogy, University of the WitwatersrandVerified email at wits.ac.za
