| Susceptibility to exacerbation in chronic obstructive pulmonary disease JR Hurst, J Vestbo, A Anzueto, N Locantore, H Müllerova, R Tal-Singer, ... New England Journal of Medicine 363 (12), 1128-1138, 2010 | 2358 | 2010 |
| The serpins are an expanding superfamily of structurally similar but functionally diverse proteins evolution, mechanism of inhibition, novel functions, and a revised nomenclature GA Silverman, PI Bird, RW Carrell, FC Church, PB Coughlin, PGW Gettins, ... Journal of Biological Chemistry 276 (36), 33293-33296, 2001 | 1340 | 2001 |
| Conformational disease RW Carrell, DA Lomas The Lancet 350 (9071), 134-138, 1997 | 1048 | 1997 |
| Characterisation of COPD heterogeneity in the ECLIPSE cohort A Agusti, PMA Calverley, B Celli, HO Coxson, LD Edwards, DA Lomas, ... Respiratory research 11 (1), 122, 2010 | 1033 | 2010 |
| The mechanism of Z α1-antitrypsin accumulation in the liver DA Lomas, LIE Dyfed, JT Finch, RW Carrell Nature 357 (6379), 605, 1992 | 1029 | 1992 |
| α1-antitrypsin deficiency JK Stoller, LS Aboussouan The Lancet 365 (9478), 2225-2236, 2005 | 800 | 2005 |
| Changes in forced expiratory volume in 1 second over time in COPD J Vestbo, LD Edwards, PD Scanlon, JC Yates, A Agusti, P Bakke, ... New England Journal of Medicine 365 (13), 1184-1192, 2011 | 769 | 2011 |
| A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci SG Pillai, D Ge, G Zhu, X Kong, KV Shianna, AC Need, S Feng, CP Hersh, ... PLoS genetics 5 (3), e1000421, 2009 | 668 | 2009 |
| Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers M Bafadhel, S McKenna, S Terry, V Mistry, C Reid, P Haldar, ... American journal of respiratory and critical care medicine 184 (6), 662-671, 2011 | 667 | 2011 |
| Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype A Agustí, LD Edwards, SI Rennard, W MacNee, R Tal-Singer, BE Miller, ... PloS one 7 (5), e37483, 2012 | 663 | 2012 |
| Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells K Yusa, ST Rashid, H Strick-Marchand, I Varela, PQ Liu, DE Paschon, ... Nature 478 (7369), 391, 2011 | 622 | 2011 |
| Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE) J Vestbo, W Anderson, HO Coxson, C Crim, F Dawber, L Edwards, ... European Respiratory Journal 31 (4), 869-873, 2008 | 570 | 2008 |
| Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells ST Rashid, S Corbineau, N Hannan, SJ Marciniak, E Miranda, ... The Journal of clinical investigation 120 (9), 3127-3136, 2010 | 560 | 2010 |
| Alpha1-Antitrypsin Deficiency — A Model for Conformational Diseases RW Carrell, DA Lomas New England Journal of Medicine 346 (1), 45-53, 2002 | 489 | 2002 |
| Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial M Bafadhel, S McKenna, S Terry, V Mistry, M Pancholi, P Venge, ... American journal of respiratory and critical care medicine 186 (1), 48-55, 2012 | 378 | 2012 |
| Familial dementia caused by polymerization of mutant neuroserpin RL Davis, AE Shrimpton, PD Holohan, C Bradshaw, D Feiglin, GH Collins, ... Nature 401 (6751), 376, 1999 | 361 | 1999 |
| Variants in FAM13A are associated with chronic obstructive pulmonary disease MH Cho, N Boutaoui, BJ Klanderman, JS Sylvia, JP Ziniti, CP Hersh, ... Nature genetics 42 (3), 200, 2010 | 352 | 2010 |
| Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease BR Celli, N Locantore, J Yates, R Tal-Singer, BE Miller, P Bakke, ... American journal of respiratory and critical care medicine 185 (10), 1065-1072, 2012 | 350 | 2012 |
| Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease DC Crowther, KJ Kinghorn, E Miranda, R Page, JA Curry, FAI Duthie, ... Neuroscience 132 (1), 123-135, 2005 | 347 | 2005 |
| Endoplasmic reticulum dysfunction in neurological disease BD Roussel, AJ Kruppa, E Miranda, DC Crowther, DA Lomas, ... The Lancet Neurology 12 (1), 105-118, 2013 | 330 | 2013 |
