| Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α M Lagouge, C Argmann, Z Gerhart-Hines, H Meziane, C Lerin, F Daussin, ... Cell 127 (6), 1109-1122, 2006 | 3586 | 2006 |
| AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity C Cantó, Z Gerhart-Hines, JN Feige, M Lagouge, L Noriega, JC Milne, ... Nature 458 (7241), 1056, 2009 | 2196 | 2009 |
| Mechanism of action of fibrates on lipid and lipoprotein metabolism B Staels, J Dallongeville, J Auwerx, K Schoonjans, E Leitersdorf, ... Circulation 98 (19), 2088-2093, 1998 | 1722 | 1998 |
| Absence of S6K1 protects against age-and diet-induced obesity while enhancing insulin sensitivity SH Um, F Frigerio, M Watanabe, F Picard, M Joaquin, M Sticker, ... Nature 431 (7005), 200, 2004 | 1608 | 2004 |
| A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity SS Deeb, L Fajas, M Nemoto, J Pihlajamäki, L Mykkänen, J Kuusisto, ... Nature genetics 20 (3), 284, 1998 | 1600 | 1998 |
| Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation M Watanabe, SM Houten, C Mataki, MA Christoffolete, BW Kim, H Sato, ... Nature 439 (7075), 484, 2006 | 1563 | 2006 |
| Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. K Schoonjans, B Staels, J Auwerx Journal of lipid research 37 (5), 907-925, 1996 | 1419 | 1996 |
| The organization, promoter analysis, and expression of the human PPARγ gene L Fajas, D Auboeuf, E Raspé, K Schoonjans, AM Lefebvre, R Saladin, ... Journal of Biological Chemistry 272 (30), 18779-18789, 1997 | 1417 | 1997 |
| Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors TT Lu, M Makishima, JJ Repa, K Schoonjans, TA Kerr, J Auwerx, ... Molecular cell 6 (3), 507-515, 2000 | 1399 | 2000 |
| PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene. K Schoonjans, J Peinado‐Onsurbe, AM Lefebvre, RA Heyman, M Briggs, ... The EMBO journal 15 (19), 5336-5348, 1996 | 1332 | 1996 |
| Transient increase in obese gene expression after food intake or insulin administration R Saladin, P De Vos, M Guerre-Millot, A Leturque, J Girard, B Staels, ... Nature 377 (6549), 527, 1995 | 1328 | 1995 |
| Sirtuins as regulators of metabolism and healthspan RH Houtkooper, E Pirinen, J Auwerx Nature reviews Molecular cell biology 13 (4), 225, 2012 | 1194 | 2012 |
| The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation K Schoonjans, B Staels, J Auwerx Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism 1302 (2), 93-109, 1996 | 1189 | 1996 |
| TGR5-mediated bile acid sensing controls glucose homeostasis C Thomas, A Gioiello, L Noriega, A Strehle, J Oury, G Rizzo, ... Cell metabolism 10 (3), 167-177, 2009 | 1097 | 2009 |
| PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure C Cantó, J Auwerx Current opinion in lipidology 20 (2), 98, 2009 | 979 | 2009 |
| A unified nomenclature system for the nuclear receptor superfamily J Auwerx, E Baulieu, M Beato, M Becker-Andre, PH Burbach, G Camerino, ... Cell 97 (2), 161-163, 1999 | 957 | 1999 |
| International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors L Michalik, J Auwerx, JP Berger, VK Chatterjee, CK Glass, FJ Gonzalez, ... Pharmacological reviews 58 (4), 726-741, 2006 | 954 | 2006 |
| Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans S Timmers, E Konings, L Bilet, RH Houtkooper, T van de Weijer, ... Cell metabolism 14 (5), 612-622, 2011 | 951 | 2011 |
| Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c M Watanabe, SM Houten, L Wang, A Moschetta, DJ Mangelsdorf, ... The Journal of clinical investigation 113 (10), 1408-1418, 2004 | 931 | 2004 |
| Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome T Tanaka, J Yamamoto, S Iwasaki, H Asaba, H Hamura, Y Ikeda, ... Proceedings of the National Academy of Sciences 100 (26), 15924-15929, 2003 | 894 | 2003 |